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?This is the last chance you have to become a part of this special setting,? explains Garrett Melahn, Community Sales Manager for The Ranch at Sheldon Hills. ?So many of today?s buyers refuse to feel bound by tiny lot sizes that have become the ?norm?. With our 2+ acre parcels, you now, literally, have 10-12 times the space of traditional neighborhood layouts. Here, your neighbor is never too close for comfort, and the chance to have that is dwindling. The last remaining luxury estate homes are under construction now and there are only three left!?
The most popular design has been the Tucson, and with only three left in the entire neighborhood, now is the time to take a look at why. Located on home sites 21, 31, and 32 they are newly released single story four bedroom, plus a den, two and a half bath, and three car side-loaded garages. The Tuscons offers an open, split floor plan with dual master bedrooms, an inviting entry that flows into an oversized family room that is geared towards entertainment, with a wall of picture windows. The final release of Tuscons offer the highly sought after ?Platinum Package? upgrades. The Platinum Option packages includes tens of thousands of dollars worth of the industry?s top of the line upgrades; Upgraded tile flooring in all wet areas, granite slab countertops with backsplash, stainless steel appliances, and dual ovens prepare you for entertaining friends and family. Situated on 2+ acres there is no other value that compares these Tuscons. You truly ?live the dream? in this home. The Scottsdale is available starting at $584,900 when using JTS?s preferred lender.
Useable Acreage
With 2 + acre parcels, you can have your home work for you. Create your own farmers market and enjoy fresh, healthy choices year round. Nowhere else in the area can you choose from so many produce and even livestock options. Your ?homestead? will save you money by becoming your personal supermarket.
?Compare the value difference in our new homes on acreage,? explains Melahn Community Sales Manager for The Ranch at Sheldon Hills, ?At Sheldon Hills our amenities extend beyond the walls of our homes. The acreage allows the privacy and usability that is so coveted in today?s market. You can create a personal retreat that will last you the rest of your life.?
*To get more information on The Ranch at Sheldon Hills, from Sacramento take Highway 50 to the Sunrise exit and go south. Turn left on Jackson Highway to Sloughhouse Rd., turn right and go two miles then turn right at the Sheldon Hills entrance to the model. The sales office is open Friday through Tuesday from 10 am to 6 pm. For more information, contact the sales office at (916) 484-5226. Broker coops are welcome and well received at 3%.
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If you have any type of vein disease or have problems dealing with issues such as Spider Veins or Varicose Veins you understand that it is a health issue that is not fun or enjoyable. This issue is a problem for many. In fact, about 50 to 55 percent of women and 40 to 45 percent of men in the United States suffer from some type of vein problem. The good news is that solutions are available. Thanks to new medical technology and years of research on everything from Deep Venous Thrombosis to Spider Veins, a lot of vein problems that are so commonly suffered in the United States can get treated well.
There are a multitude of treatments that are available for Vein Disease and it is up to you to decide which one will have the greatest impact on helping out your cause. The doctor that you visit in your initial appointment to discuss treatment options will go over all of the potential options available. Below, we have analyzed various treatment options that are available to people today and have gone over their advantages and disadvantages. Each option has unique benefits and drawbacks and it is ultimately up to you to decide, but based on the lists below, you should gain better knowledge as what treatment option will best suite your specific needs.
The first option is a procedure called Sclerotherapy. Sclerotherapy is a safe and proven non-surgical treatment for small or medium-sized varicose veins and is best for the treatment for spider veins. A tiny needle is used to implement a sclerosing solution into the target vein. This solution shuts it down the vein by irritating the lining of it.
Another option is called Endovenous laser Treatment (EVLT). This procedure is a minimally invasive treatment for veins that are located beneath the skins surface which are not working properly due to malfunctioning valves. The procedure involves the insertion of a tiny laser fiber into the vein, which seals the vein shut so it eventually collapses and fades from the surface of the skin.
The next option available is VNUS. This is a new procedure utilizes radiofrequency waves created by an electrode to close the vein. It closes the vein by heating the vein wall causing contraction of the vein. The VNUS Closure procedure has very little discomfort associated with it and yields a typically high degree of success.
Microphlebectomy is a procedure that is also commonly referred to as ambulatory phlebectomy. This is a type of surgery commonly used to remove large bulging veins. Many times, varicose veins near the surface of the skin are too large to treat with Sclerotherapy and are too small to treat with laser ablation. In these cases, this procedure is recommended to treat unsightly or painful leg veins close to the skins surface. Even though this is an invasive surgery, the risks associated are minimal.
As you see above, there is a great deal of options available to you for treatment of Vein Disease. Make sure you go over the options thoroughly and choose the treatment that fits your needs the best!
See more information about vein diseases and how to get the right treatment for your condition. Visit the following links: Varicose vein and Varicose vein doctor.
Visit our website at http://www.californiaveintreatment.com
Source: http://www.articleswide.com/article/12137-Treatment_options_for_Vein_diseases.html
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ATLANTA - Police say the wife of former Atlanta Braves star Andruw Jones accused him of dragging her down a staircase, grabbing her neck and saying he wanted to kill her.
A police report obtained by The Associated Press says the fight happened around 1:30 a.m. on Christmas Day, after Nicole Jones asked her husband to help her prepare their home for Christmas morning.
Andruw Jones was free on bond after being arrested in Duluth on a battery charge, according to Gwinnett County Jail records. It wasn't known Wednesday whether he has an attorney.
Nicole Jones told officers she tried to escape upstairs, but her husband grabbed her by the ankle and dragged her downstairs, got on top of her and said, "I want to kill you," according to the report.
Source: http://news.yahoo.com/police-former-braves-star-andruw-jones-accused-dragging-162200363--spt.html
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DAVIS, Calif. (CBS/AP) ? A veterinarian at the University of California, Davis has some good news about a dog from the Philippines who became an international hero after sacrificing its snout to save two young girls.
Veterinarian Gina Davis said the dog named Kabang appears to have beaten the cancer it was suffering from.
Kabang, however, is still facing treatment for heartworms in its arteries before it can have the gaping wound on its face closed.
Newspapers in the Philippines have reported that Kabang had her snout and upper jaw sheared off when she jumped in front of a speeding motorcycle, saving her owner?s daughter and niece who were apparently about to be hit.
Kabang ended up in Davis earlier this year after a nurse from Buffalo, N.Y. spearheaded a fundraising campaign to bring her to the U.S.
(Copyright 2012 by CBS San Francisco. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
38.544907 -121.740517
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![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 24-Dec-2012
Share ] Contact: Klaus Nusslein
nusslein@microbio.umass.edu
413-545-1356
University of Massachusetts at Amherst
AMHERST, Mass. An international team of microbiologists led by Klaus Nsslein of the University of Massachusetts Amherst has found that a troubling net loss in diversity among the microbial organisms responsible for a functioning ecosystem is accompanying deforestation in the Amazon rainforest.
Nsslein, an expert in tropical rain forest microbial soil communities, says, "We found that after rainforest conversion to agricultural pastures, bacterial communities were significantly different from those of forest soils. Not only did the pasture soils show increased species numbers, these species were also less related to one another than in rainforest soil. This is important because the combination of lost forest species and the homogenization of pasture communities together signal that this ecosystem is now a lot less capable of dealing with additional outside stress."
He and colleagues studied a large farm site over the past four years at the frontier where farmers drive agriculture into pristine rainforest in Rondonia, Brazil, to convert rainforest to agricultural use. Findings in part validated previous research showing that bacteria in the soil became more diverse after conversion to pasture. However, in its fourth year, their study overcame limitations of earlier investigations to show that changes in microbial diversity occurred over larger geographic scales. Results appear in the current issue of Proceedings of the National Academy of Sciences.
In addition to Nsslein at UMass Amherst, the research group includes first author Jorge Rodrigues at the University of Texas at Arlington with Brendan Bohannan at the University of Oregon, James Tiedje at Michigan State University, and others at the University of Sao Paulo. Lead investigators Nsslein and Rodrigues emphasize that the study is an equal collaboration among the four research groups.
Findings do not support earlier study conclusions, instead they show that the loss of restricted ranges for different bacteria communities results in a biotic homogenization and net loss of diversity overall. Scientists worry that the loss of genetic variation in bacteria across a converted forest could reduce ecosystem resilience. The researchers hope their work will provide valuable data to those making decisions about the future of the Amazon rainforest.
Biologist and first author Jorge Rodrigues of the University of Texas at Arlington adds, "We have known for a long time that conversion of rainforest land in the Amazon for agriculture results in a loss of biodiversity in plants and animals. Now we know that microbial communities which are so important to the ecosystem also suffer significant losses."
As Nsslein and colleagues point out, the Amazon represents half of the world's rainforest and is home to one-third of Earth's species, yet the Amazon has one of the highest rates of deforestation. Agriculture is one of the largest and most dynamic parts of Brazil's economy, so dealing with standing rainforests in the tropics will be tricky, but nevertheless, it is vital that the issue is tackled."
Rodrigues says he and colleagues are currently compiling findings about the potential for recovery of the microbial diversity after pastureland is abandoned and returned to "secondary forest." At the same time, Nsslein and colleagues are leading an effort to investigate how the redundancy of functions provided by soil microbes provides resilience to the effects of agricultural land use change to support a stressed ecosystem to recover stability.
"Whether bacterial diversity will completely recover from ecosystem conversion will depend in part on whether the taxa lost due to conversion are truly locally extinct or whether they are present in the pasture sites but of such low abundance that they are undetectable in our study," the authors write.
###
This work was supported by grants from the USDA National Institute of Food and Agriculture and the Research Support Foundation of the State of So Paulo.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 24-Dec-2012 Share ] Contact: Klaus Nusslein
nusslein@microbio.umass.edu
413-545-1356
University of Massachusetts at Amherst
AMHERST, Mass. An international team of microbiologists led by Klaus Nsslein of the University of Massachusetts Amherst has found that a troubling net loss in diversity among the microbial organisms responsible for a functioning ecosystem is accompanying deforestation in the Amazon rainforest.
Nsslein, an expert in tropical rain forest microbial soil communities, says, "We found that after rainforest conversion to agricultural pastures, bacterial communities were significantly different from those of forest soils. Not only did the pasture soils show increased species numbers, these species were also less related to one another than in rainforest soil. This is important because the combination of lost forest species and the homogenization of pasture communities together signal that this ecosystem is now a lot less capable of dealing with additional outside stress."
He and colleagues studied a large farm site over the past four years at the frontier where farmers drive agriculture into pristine rainforest in Rondonia, Brazil, to convert rainforest to agricultural use. Findings in part validated previous research showing that bacteria in the soil became more diverse after conversion to pasture. However, in its fourth year, their study overcame limitations of earlier investigations to show that changes in microbial diversity occurred over larger geographic scales. Results appear in the current issue of Proceedings of the National Academy of Sciences.
In addition to Nsslein at UMass Amherst, the research group includes first author Jorge Rodrigues at the University of Texas at Arlington with Brendan Bohannan at the University of Oregon, James Tiedje at Michigan State University, and others at the University of Sao Paulo. Lead investigators Nsslein and Rodrigues emphasize that the study is an equal collaboration among the four research groups.
Findings do not support earlier study conclusions, instead they show that the loss of restricted ranges for different bacteria communities results in a biotic homogenization and net loss of diversity overall. Scientists worry that the loss of genetic variation in bacteria across a converted forest could reduce ecosystem resilience. The researchers hope their work will provide valuable data to those making decisions about the future of the Amazon rainforest.
Biologist and first author Jorge Rodrigues of the University of Texas at Arlington adds, "We have known for a long time that conversion of rainforest land in the Amazon for agriculture results in a loss of biodiversity in plants and animals. Now we know that microbial communities which are so important to the ecosystem also suffer significant losses."
As Nsslein and colleagues point out, the Amazon represents half of the world's rainforest and is home to one-third of Earth's species, yet the Amazon has one of the highest rates of deforestation. Agriculture is one of the largest and most dynamic parts of Brazil's economy, so dealing with standing rainforests in the tropics will be tricky, but nevertheless, it is vital that the issue is tackled."
Rodrigues says he and colleagues are currently compiling findings about the potential for recovery of the microbial diversity after pastureland is abandoned and returned to "secondary forest." At the same time, Nsslein and colleagues are leading an effort to investigate how the redundancy of functions provided by soil microbes provides resilience to the effects of agricultural land use change to support a stressed ecosystem to recover stability.
"Whether bacterial diversity will completely recover from ecosystem conversion will depend in part on whether the taxa lost due to conversion are truly locally extinct or whether they are present in the pasture sites but of such low abundance that they are undetectable in our study," the authors write.
###
This work was supported by grants from the USDA National Institute of Food and Agriculture and the Research Support Foundation of the State of So Paulo.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-12/uoma-adb122012.php
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Dec. 23, 2012 ? A research team led by biogeochemists at the University of California, Riverside has tested a popular hypothesis in paleo-ocean chemistry, and proved it false.
The fossil record indicates that eukaryotes -- single-celled and multicellular organisms with more complex cellular structures compared to prokaryotes, such as bacteria -- show limited morphological and functional diversity before 800-600 million years ago. Many researchers attribute the delayed diversification and proliferation of eukaryotes, which culminated in the appearance of complex animals about 600 million years ago, to very low levels of the trace metal zinc in seawater.
As it is for humans, zinc is essential for a wide range of basic cellular processes. Zinc-binding proteins, primarily located in the cell nucleus, are involved in the regulation of gene transcription.
Eukaryotes have increasingly incorporated zinc-binding structures during the last third of their evolutionary history and still employ both early- and late-evolving zinc-binding protein structures. Zinc is, therefore, of particular importance to eukaryotic organisms. And so it is not a stretch to blame the 1-2-billion-year delay in the diversification of eukaryotes on low bioavailability of this trace metal.
But after analyzing marine black shale samples from North America, Africa, Australia, Asia and Europe, ranging in age from 2.7 billion years to 580 million years old, the researchers found that the shales reflect high seawater zinc availability and that zinc concentrations during the Proterozoic (2.5 billion to 542 million years ago) were similar to modern concentrations. Zinc, the researchers posit, was never biolimiting.
Study results appear online Dec. 23 in Nature Geoscience.
"We argue that the concentration of zinc in ancient marine black shales is directly related to the concentrations of zinc in seawater and show that zinc is abundant in these rocks throughout Earth's history," said Clint Scott, the first author of the research paper and a former UC Riverside graduate student. "We found no evidence for zinc biolimitation in seawater."
Scott, now a research geologist with the U.S. Geological Survey, explained that the connection between zinc limitation and the evolution of eukaryotes was based largely on the hypothesis that Proterozoic oceans were broadly sulfidic. Under broadly sulfidic conditions, zinc should have been scarce because it would have rapidly precipitated in the oceans, he explained.
"However, a 2011 research paper in Nature also published by our group at UCR demonstrated that Proterozoic oceans were more likely broadly ferruginous -- that is, low in oxygen and iron-rich -- and that sulfidic conditions were more restricted than previously thought," said Scott, who performed the research in the lab of Timothy Lyons, a professor of biogeochemistry and the principal investigator of the research project.
The research team argues that ferruginous deep oceans, combined with large hydrothermal fluxes of zinc via volcanic activity on the seafloor, maintained high levels of dissolved zinc throughout the oceans and provided a relatively stable marine reservoir of the trace metal over the past 2.7 billion years.
"The key challenge in understanding the early evolution of life is recognizing the environmental conditions under which that life first appeared and diversified," Lyons said. "We have taken a very direct approach that specifically tracks the availability of essential micronutrients, and, to our surprise, zinc supplies in ancient seawater were much higher and less variable than previously imagined.
"We can imagine for the first time," he quipped, "that zinc supplements were not on the shopping lists of our early eukaryotic ancestors, and so we better find another reason to explain the mysterious delay in their rise in the ocean."
Scott, who graduated with a doctoral degree in geological sciences from UCR in 2009, and Lyons were joined in the study by Noah J. Planavsky, a former UCR graduate student in Lyons' lab; Chris L. Dupont at the J. Craig Venter Institute, La Jolla, Calif.; Brian Kendall and Ariel D. Anbar at Arizona State University; Benjamin C. Gill at Virginia Polytechnic Institute and State University and also a former member of the Lyons lab; Leslie J. Robbins and Kurt O. Konhauser at the University of Alberta, Canada; Kathryn F. Husband and Simon W. Poulton at the University of Leeds, United Kingdom; Gail L. Arnold at the Max Planck Institute for Marine Microbiology, Germany; Boswell A. Wing at McGill University, Canada; and Andrey Bekker at the University of Manitoba, Canada.
The idea for the study was a direct consequence of the 2011 Nature paper by Planavsky, Scott, Lyons and others that challenged the hypothesis of broadly sulfidic oceans.
The international collaboration received funding for the study from numerous sources. In the U.S., funding came from the National Science Foundation, the NASA Astrobiology Institute and the Agouron Institute.
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The above story is reprinted from materials provided by University of California - Riverside. The original article was written by Iqbal Pittalwala.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/DC5qaP7AZPY/121223152736.htm
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Source: http://the-gadgeteer.com/2012/12/24/whip-your-photo-sharing-into-shape-with-the-whip-app/
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The incumbent will teach a total of five courses including an introductory course on organismal biology and a post-introductory course on vertebrate morphology (with a focus on evolution and/or biomechanics) or on developmental biology. Additional courses will be post-introductory in the incumbent's areas of specialization.
Among the qualifications required for appointment is the Ph.D. degree (in hand or expected by September 1, 2013). Candidates must demonstrate interest and potential excellence in undergraduate teaching. Successful teaching experience at the college level is highly desirable.
Please submit as a single pdf document to morphologistsearch@oberlin.edu, a cover letter, curriculum vitae, and description of teaching philosophy. Also, please have graduate and undergraduate academic transcripts and three recent letters of reference* sent directly to Morphologist Search, Biology Department, Oberlin College, 119 Woodland Street, Science Center K123, Oberlin, Ohio, 44074-1097. Review of applications will commence on February 11, 2013; application materials received after that date may be considered until the position is filled. *By providing these letters you agree that we may contact your references.
Oberlin College is an Equal Opportunity/Affirmative Action Employer committed to creating an institutional environment free from discrimination and harassment based on race, color, sex, marital status, religion, creed, national origin, disability, age, military or veteran status, sexual orientation, family relationship to an employee of Oberlin College, and gender identity and expression.
Oberlin was the first coeducational institution to grant bachelor's degrees to women and historically has been a leader in the education of African Americans; the College was also among the first to prohibit discrimination based on sexual orientation. In that spirit, we are particularly interested in receiving applications from individuals who would contribute to the diversity of our faculty in all respects.
Oberlin College is an Equal Opportunity/Affirmative Action Employer committed to creating an institutional environment free from discrimination and harassment based on race, color, sex, marital status, religion, creed, national origin, disability, age, military or veteran status, sexual orientation, family relationship to an employee of Oberlin College, and gender identity and expression.
Source: http://www.higheredjobs.com/details.cfm?JobCode=175704476
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Every year, Alpine?s Christmas party gets bigger, better, and crazier. This year we had two special guests. First, owner Brent Dodge showed up wearing a Christmas tree, complete with a glowing star on top. Some people were stumped that the tree was marked with ?AL? on the front; others figured out that the tree was, of course, a pine . . . an ?Al? Pine!
And then at 9 PM, after plenty of food, drink, white elephants, and Karaoke, our second special guest arrived. His initials? Mr. MB! That?s right Mr. Mechanical Bull. Heavy on the Mister! Who?d a thought that Mr. MB could inspire so many of our team to get on their spurs, and take him for a spin. But they did. The rest was Alpine history. Check out these folks in all their rodeo glory! (Though most of the glory was short-lived, ending in near-whiplash and a thud, every time!)
?
Source: http://healthandfitness101.com/?p=3407
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NEW YORK (AP) ? FedEx, the world's second-largest package delivery company, posted a 12 percent decline in second-quarter profits Wednesday due to weakness in its air network and the impact of Superstorm Sandy.
The storm shaved 11 cents per share off of earnings for the quarter as shipping volumes fell and costs rose.
The company maintained its forecast for the full fiscal year ending in May, counting on a massive cost cutting plan to offset global economic weakness. Its forecast for the current quarter, which incorporates the critical holiday season, falls below Wall Street expectations.
FedEx Corp. posted earnings of $438 million, or $1.39 per share for the quarter that ending in November, compared with $497 million, or $1.57 per share, a year ago. That fell shy of the $1.41 per share that Wall Street was expecting, according to a poll of analysts by FactSet.
Revenue rose to $11.1 billion from $10.6 billion previously, as the company scaled back its operation to better match demand and some of its raised rates. Analysts forecast revenue of $10.84 billion.
Growth in the company's freight and ground operations boosted results, but FedEx reported "persistent weakness" in its core express network. Operating income in that segment fell 33 percent. FedEx and its larger rival UPS Inc. have both seen consumers and businesses opt for slower shipping options to cut costs.
FedEx said on Wednesday that it expects earnings will be between $1.25 and $1.45 per share in the third quarter. Analysts that follow the company were predicting per-share earnings of $1.45.
The company also said it expects to earn between $6.20 and $6.60 per share for the year ending in May, excluding any charges from the company's buyout plan. Wall Street is looking for $6.34.
Earlier this month FedEx said it will offer some employees up to two years pay to leave, starting next year. The voluntary program is part of an effort to cut annual costs by $1.7 billion within three years.
Shares of FedEx, based in Memphis, Tenn., rose slightly before the opening bell.
Source: http://news.yahoo.com/fedex-2q-earnings-fall-weak-air-segment-sandy-125041478--finance.html
Actually, there is a source of free advice and support. The Small Business Development Center (SBDC) of Polk County, an agency administered by the Polk County Commission, assists locally owned businesses with financial analyses, marketing assistance, preparation of loan packages, and other services.
The center operates under the umbrella of the Central Florida Development Council, Polk County?s official economic development organization. Funding for the SBDC comes from taxes paid for county business licenses and from a grant provided by the Florida Small Business Development Center Network, said Dawn Decaminada, the county agency?s certified business analyst. The state?network is one of eight original pilot programs first funded in 1976 by the U.S. Small Business Administration. The federal grant program requires matching funding from a local entity.
The center?s budget of $343,635 includes $125,000 that filters down from the Small Business Administration through state and regional agencies. The county provides nearly $220,000 in funds and in-kind services.
Decaminada, the Polk agency?s only certified business consultant, said her agency?s services are available to any Polk business with 500 or fewer employees. While she devotes much of her time to advising startup businesses, she said she also assists existing businesses looking to expand or seeking new loans.
Decaminada works in the Neil Combee Administration Building in Bartow.
She said that location makes it easy for her to advise clients on such matters as needed permits by directing them to county departments based in the same building.
Polk County?s Small Business Development Center is unusual in being overseen by county government, Decaminada said. Most such centers, she said, are supported by universities.
Decaminada said she is careful to avoid telling entrepreneurs what they should do. She said her role is to examine business plans and ask probing questions.
?I make them give me the numbers,? she said.
Decaminada said the county has tools that can help entrepreneurs decide if their plans are feasible. For example, she said she can pull up demographic data for the entire county or specific areas. Though she?s based in Bartow, Decaminada said she travels the county on ?circuit rides,? meeting clients at their offices.
Anyone interested in seeking assistance from the Small Business Development Center may call 863-534-5915 or contact Decaminada at?dawn@cfdc.org.
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Public release date: 17-Dec-2012 Share ] Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
ROCHESTER, Minn. -- A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span. The findings appear in today's online issue of Nature Cell Biology.
"We've known for some time that reduced levels of BubR1 are a hallmark of aging and correspond to age-related conditions, including muscle weakness, cataract formation and tumor growth," says co-author Jan van Deursen, Ph.D., of Mayo Clinic. "Here we've shown that a high abundance of BubR1, a regulator of chromosome segregation during mitosis, preserves genomic integrity and reduces tumors, even in the face of some genetic alterations that promote inaccurate cell division. Our findings suggest that controlling levels of this regulator provides a unique opportunity to extend healthy life span."
Researchers studied two lines of transgenic mice, one with moderate expression of BubR1 and the other with high expression. Outcomes of a series of experiments showed that mice with high expression of the gene were dramatically effective in preventing or limiting age-related disease compared to those with moderate expression and especially to wild type mice.
The findings were significant. Only 33 percent of these high expressing mice developed lung and skin tumors compared to 100 percent of the control group. BubR1 overexpression markedly reduced aneuploidy (a state of having an abnormal number of chromosomes), which causes birth defects. Other results showed these mice were protected from muscle fiber deterioration, that they were better performers in treadmill tests, that they had much reduced levels of renal sclerosis, intestinal fibrosis and tubular atrophy -- all signs of aging. They also showed higher cardiac-stress tolerance and resistance to age-related retinal atrophy.
Co-author Darren Baker, Ph.D., of Mayo Clinic, says the findings show BubR1 and its associated regulators are "promising targets for a broad spectrum of aneuploid human cancers and key age-related disorders that dictate human health."
###
The research was supported by the National Institutes of Health grant CA96985, the Ellison Medical Foundation, the Noaber Foundation and the Robert and Arlene Kogod Center on Aging.
Co-authors include Meelad Dawlaty, Ph.D.; Karthik Jegnathan; Liviu Malureanu, M.D.; Janine van Ree, Ph.D.; Ruben Crespo-Diaz, Ph.D.; Santiago Reyes, Ph.D.; Lauren Seaburg; Virginia Shapiro, Ph.D.; Atta Behfar, M.D., Ph.D., and Andre Terzic, M.D., Ph.D.; all of Mayo Clinic; and Tobias Wijshake, and Bart van de Sluis, Ph.D., of the University of Groningen, The Netherlands. Drs. Baker and Dawlaty are joint first authors. Dr. van Deursen is the Vita Valley Professor of Cell Senescence at Mayo Clinic and holds a joint appointment in the Department of Pediatric and Adolescent Medicine and is chair of the Department of Biochemistry and Molecular Biology. Dr. Terzic is the Marriott Family Professor at Mayo Clinic.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit www.mayoclinic.com and www.mayoclinic.org/news.
Journalists can become a member of the Mayo Clinic News Network for the latest health, science and research news and access to video, audio, text and graphic elements that can be downloaded or embedded.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 17-Dec-2012 Share ] Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
ROCHESTER, Minn. -- A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span. The findings appear in today's online issue of Nature Cell Biology.
"We've known for some time that reduced levels of BubR1 are a hallmark of aging and correspond to age-related conditions, including muscle weakness, cataract formation and tumor growth," says co-author Jan van Deursen, Ph.D., of Mayo Clinic. "Here we've shown that a high abundance of BubR1, a regulator of chromosome segregation during mitosis, preserves genomic integrity and reduces tumors, even in the face of some genetic alterations that promote inaccurate cell division. Our findings suggest that controlling levels of this regulator provides a unique opportunity to extend healthy life span."
Researchers studied two lines of transgenic mice, one with moderate expression of BubR1 and the other with high expression. Outcomes of a series of experiments showed that mice with high expression of the gene were dramatically effective in preventing or limiting age-related disease compared to those with moderate expression and especially to wild type mice.
The findings were significant. Only 33 percent of these high expressing mice developed lung and skin tumors compared to 100 percent of the control group. BubR1 overexpression markedly reduced aneuploidy (a state of having an abnormal number of chromosomes), which causes birth defects. Other results showed these mice were protected from muscle fiber deterioration, that they were better performers in treadmill tests, that they had much reduced levels of renal sclerosis, intestinal fibrosis and tubular atrophy -- all signs of aging. They also showed higher cardiac-stress tolerance and resistance to age-related retinal atrophy.
Co-author Darren Baker, Ph.D., of Mayo Clinic, says the findings show BubR1 and its associated regulators are "promising targets for a broad spectrum of aneuploid human cancers and key age-related disorders that dictate human health."
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The research was supported by the National Institutes of Health grant CA96985, the Ellison Medical Foundation, the Noaber Foundation and the Robert and Arlene Kogod Center on Aging.
Co-authors include Meelad Dawlaty, Ph.D.; Karthik Jegnathan; Liviu Malureanu, M.D.; Janine van Ree, Ph.D.; Ruben Crespo-Diaz, Ph.D.; Santiago Reyes, Ph.D.; Lauren Seaburg; Virginia Shapiro, Ph.D.; Atta Behfar, M.D., Ph.D., and Andre Terzic, M.D., Ph.D.; all of Mayo Clinic; and Tobias Wijshake, and Bart van de Sluis, Ph.D., of the University of Groningen, The Netherlands. Drs. Baker and Dawlaty are joint first authors. Dr. van Deursen is the Vita Valley Professor of Cell Senescence at Mayo Clinic and holds a joint appointment in the Department of Pediatric and Adolescent Medicine and is chair of the Department of Biochemistry and Molecular Biology. Dr. Terzic is the Marriott Family Professor at Mayo Clinic.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit www.mayoclinic.com and www.mayoclinic.org/news.
Journalists can become a member of the Mayo Clinic News Network for the latest health, science and research news and access to video, audio, text and graphic elements that can be downloaded or embedded.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-12/mc-mcs_1121712.php
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(Reuters) - Sun Life Financial Inc
Sun Life said in December it would stop selling variable annuities and individual life products in the United States to focus more on group insurance and voluntary benefits.
It had billed its decision to pull out of the two capital-intensive businesses, which had become a drag on its earnings, as the start of a "new chapter."
Sun Life said on Monday it expects the sale to Delaware Life Holdings to result in a reduction in book value of C$950 million ($963 million) when the deal closes by the end of the second quarter of 2013.
Sun Life said the transaction is expected to reduce its 2013 earnings by 22 Canadian cents per share.
People familiar with the matter earlier told Reuters that Guggenheim Partners had emerged as the lead bidder for Sun Life's variable annuity business.
The deal is expected to result in a cash of C$1.9 billion, net of a planned repayment of C$350 million of debt in June 2013, Sun Life said in a statement.
Morgan Stanley & Co advised Sun Life on the transaction.
(Reporting by Bhaswati Mukhopadhyay in Bangalore; Editing by Sriraj Kalluvila)
Source: http://news.yahoo.com/sun-life-sell-u-annuity-business-1-35-123612105--sector.html
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Public release date: 17-Dec-2012 Share ] Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining the oxidation state of a small molecule called glutathione in cell extracts. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have been the first to discover that cells under stress deposit their oxidized glutathione in a cellular waste repository. This protects cells from oxidative stress and questions the validity of the conventional measuring method.
Cancer, Alzheimer's, arteriosclerosis the list of diseases which have been linked to oxidative stress is long and even includes the very process of aging. Oxidative stress is caused by so-called reactive oxygen compounds, which include the notorious "free radicals". If a cell is exposed to more reactive oxygen compounds than it can instantly degrade, it is under oxidative stress. As a result, important components such as proteins, DNA and lipids are oxidized and thus get damaged.
To determine whether a cell is under oxidative stress, scientists often analyze the oxidation state of glutathione. Glutathione is a small molecule which gets oxidized to protect the cell from reactive oxygen compounds. In theory, the amount of oxidized glutathione should therefore indicate whether a cell is healthy or under oxidative stress. However, researchers in the team of Associate Professor (PD) Dr. Tobias Dick have demonstrated that this hypothesis, which is the basis of a large number of scientific studies, is deceptive.
"Up to now, it was necessary to destroy the cells in order to measure the amount of oxidized glutathione," Tobias Dick explains. "However, this means that any spatial resolution is lost." Therefore, virtually nothing was known about where exactly oxidized glutathione is found in the cells. Scientists have presumed that it remains in the cytoplasm, where it is formed.
To find out more about the whereabouts of glutathione in the cell, Tobias Dick and co-workers developed biosensors which indicate the oxidation state of glutathione in intact cells by releasing light signals. In yeast cells, the researchers were able, for the first time, to follow the path of oxidized glutathione through the living cell in real time. They were surprised to find that, rather than remaining in the cytoplasm, it promptly gets locked up in a safe depot, the vacuole.
The cytoplasm, where all important cellular metabolic processes happen, is thus reliably protected from oxidative damage. Cells that would have been considered to be under oxidative stress using the conventional method appeared entirely healthy in their cytoplasm. Tobias Dick and his team could subsequently show that this is not only true for yeast cells but also for various mammalian cells and also for cancer cells.
These results mean that contrary to previously held beliefs the level of oxidative glutathione does not indicate whether or not a cell is under oxidative stress. "Therefore, it is important to re-evaluate prior studies that have established a link between oxidative stress and various diseases based on the conventional method."
###
A picture for this press release is available at: http://www.dkfz.de/de/presse/pressemitteilungen/2012/images/66-hefe-wt1.jpg
Picture caption: A biosensor tracks oxidized glutathione in the vacuole of yeast cells.
Source: Tobias Dick, German Cancer Research Center
Bruce Morgan, Daria Ezeri?a, Theresa N.E. Amoako, Jan Riemer, Matthias Seedorf and Tobias P. Dick: Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nature Chemical Biology 2012, DOI: 10.1038/NCHEMBIO.1142
The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg where promising approaches from cancer research are translated into the clinic. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. The center is a member of the Helmholtz Association of National Research Centers. Ninety percent of its funding comes from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 17-Dec-2012 Share ] Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining the oxidation state of a small molecule called glutathione in cell extracts. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have been the first to discover that cells under stress deposit their oxidized glutathione in a cellular waste repository. This protects cells from oxidative stress and questions the validity of the conventional measuring method.
Cancer, Alzheimer's, arteriosclerosis the list of diseases which have been linked to oxidative stress is long and even includes the very process of aging. Oxidative stress is caused by so-called reactive oxygen compounds, which include the notorious "free radicals". If a cell is exposed to more reactive oxygen compounds than it can instantly degrade, it is under oxidative stress. As a result, important components such as proteins, DNA and lipids are oxidized and thus get damaged.
To determine whether a cell is under oxidative stress, scientists often analyze the oxidation state of glutathione. Glutathione is a small molecule which gets oxidized to protect the cell from reactive oxygen compounds. In theory, the amount of oxidized glutathione should therefore indicate whether a cell is healthy or under oxidative stress. However, researchers in the team of Associate Professor (PD) Dr. Tobias Dick have demonstrated that this hypothesis, which is the basis of a large number of scientific studies, is deceptive.
"Up to now, it was necessary to destroy the cells in order to measure the amount of oxidized glutathione," Tobias Dick explains. "However, this means that any spatial resolution is lost." Therefore, virtually nothing was known about where exactly oxidized glutathione is found in the cells. Scientists have presumed that it remains in the cytoplasm, where it is formed.
To find out more about the whereabouts of glutathione in the cell, Tobias Dick and co-workers developed biosensors which indicate the oxidation state of glutathione in intact cells by releasing light signals. In yeast cells, the researchers were able, for the first time, to follow the path of oxidized glutathione through the living cell in real time. They were surprised to find that, rather than remaining in the cytoplasm, it promptly gets locked up in a safe depot, the vacuole.
The cytoplasm, where all important cellular metabolic processes happen, is thus reliably protected from oxidative damage. Cells that would have been considered to be under oxidative stress using the conventional method appeared entirely healthy in their cytoplasm. Tobias Dick and his team could subsequently show that this is not only true for yeast cells but also for various mammalian cells and also for cancer cells.
These results mean that contrary to previously held beliefs the level of oxidative glutathione does not indicate whether or not a cell is under oxidative stress. "Therefore, it is important to re-evaluate prior studies that have established a link between oxidative stress and various diseases based on the conventional method."
###
A picture for this press release is available at: http://www.dkfz.de/de/presse/pressemitteilungen/2012/images/66-hefe-wt1.jpg
Picture caption: A biosensor tracks oxidized glutathione in the vacuole of yeast cells.
Source: Tobias Dick, German Cancer Research Center
Bruce Morgan, Daria Ezeri?a, Theresa N.E. Amoako, Jan Riemer, Matthias Seedorf and Tobias P. Dick: Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nature Chemical Biology 2012, DOI: 10.1038/NCHEMBIO.1142
The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg where promising approaches from cancer research are translated into the clinic. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. The center is a member of the Helmholtz Association of National Research Centers. Ninety percent of its funding comes from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-12/haog-pdf121712.php
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A chimney fire damaged a home at 1814 W. Mission in northwest Spokane this morning just after 9 a.m. Three residents made it safely out of the home, as did two cats and several birds.
Firefighters found smoke and flames on an exterior wall on the first floor when they arrived, according to a Spokane Fire Department press release. The fire was spreading to the second floor and attic. Crews had to rip open the walls and attic to put out the fire.
Investigators determined that the fire was caused by a wood stove chimney that set the wall on fire, the press release said. Damage is estimated to be at least $20,000. The Red Cross is assisting the?residents.
Source: http://www.spokesman.com/stories/2012/dec/16/people-pets-flee-chimney-fire/
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Source: http://kulsumkatun7.blogspot.com/2012/12/scottcarreey-courses-for-boating-sports.html
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Petr David Josek / AP
Soldiers walk past a military tank securing the presidential palace in Cairo, Egypt, Thursday, Dec. 13, 2012. Egypt's opposition called on its followers to vote "no" in a crucial referendum on a disputed constitution drafted by Islamist supporters of President Mohammed Morsi. (AP Photo/Petr David Josek)
NBC News correspondent Ayman Mohyeldin and others gathered on Thursday at 12 p.m. ET (7 p.m. Cairo time) to discuss Egypt's draft constitution and whether it is good or bad for the country. They examined lessons and mistakes learned, and whether or not it will protect and defend the rights of women and minorities. To watch a replay of the chat, please click on the video below.?
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